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目的 探讨突发性聋患者体内一氧化氮 (NO)、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH -Px)、丙二醛 (MDA)水平的变化及其临床意义。方法 测定 30例突发性聋患者和 2 0例正常健康人血浆NO、SOD、GSH -Px、MDA的浓度。结果 与正常对照组相比 ,突发性聋患者血浆NO、SOD、GSH -Px浓度显著低于正常对照组 ,而MDA水平显著高于正常对照组 (P <0 .0 1) ;不同程度耳聋组之间NO、GHS -Px无显著性差异 ,而在SOD、MDA之间的差异有显著性。治疗后血浆NO、SOD、GSH -Px的活性明显升高。MDA水平明显降低 ,与治疗前相比有显著性差异。结论 突发性聋患者体内NO、SOD、GSH -Px含量下降 ,而MDA水平增高 ,建议治疗该病可应用NO合成诱导剂和外源性SOD或其他抗氧化剂 ,以提高突发性聋的治疗效果。
Objective To investigate the changes of nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in patients with sudden deafness and its clinical significance significance. Methods Plasma concentrations of NO, SOD, GSH-Px and MDA were measured in 30 cases of sudden deafness and 20 normal controls. Results Compared with the normal control group, the concentrations of NO, SOD and GSH-Px in patients with sudden deafness were significantly lower than those in the normal control group and MDA levels were significantly higher than those in the normal control group (P <0.01) NO, GHS-Px between the groups no significant difference, but in the SOD, MDA differences between the significant. After treatment, plasma NO, SOD, GSH-Px activity was significantly increased. MDA levels decreased significantly, compared with before treatment were significantly different. Conclusions In patients with sudden deafness, NO, SOD and GSH-PX levels are decreased and MDA level is increased. It is suggested that NO synthesis inducer and exogenous SOD or other antioxidants should be used to improve the treatment of sudden deafness effect.