奥美拉唑(Omeprazole)是新的苯并咪唑类质子泵阻滞剂,抑制胃壁细胞的酸分泌,治疗胃溃疡优于H_2受体拮抗剂,能治愈后者不能治疗的溃疡,可治疗佐林格-埃利森综合征。在体内广泛代谢为砜(OPZ-SFN)、羟化物(H-OPZ)和硫醚(OPZ-SFD)三种代谢物,血浆中主要存在有OPZ-SFN和H-OPZ,OPZ-SFD浓度太低不易检测到。尿中主要存在H-OPZ,而OPZ-SFN、OPZ-SFD几乎可忽略不计。本品在碱性、中性下稳定,而在 Omeprazole, a new benzimidazole proton pump inhibitor, inhibits gastric acid secretion in gastric parietal cells. It is superior to H 2 receptor antagonists in the treatment of gastric ulcer and can cure the latter which can not cure ulcer. Ringer-Ellison syndrome. In the body widely metabolized to the three sulfone (OPZ-SFN), hydroxylated (H-OPZ) and thioether (OPZ-SFD) metabolites, the main presence of plasma OPZ-SFN and H-OPZ, OPZ-SFD concentration too Low not easy to detect. The main presence of urine H-OPZ, and OPZ-SFN, OPZ-SFD is almost negligible. This product is alkaline, neutral stability, while