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白细胞介素 2 (IL 2 )是T细胞活化分泌 ,能与T细胞上IL 2R结合后 ,增强T细胞增殖的一种重要的细胞因子。CD3AK细胞是利用抗CD3单克隆抗体与TCR/CD3 复合体的结合 ,同时提供少量外源IL 2 ,激活产生的具有细胞毒效应的杀伤细胞 ,常用于过继免疫治疗。临床资
Interleukin 2 (IL 2) is an important cytokine that T cell activation and secretion can enhance T cell proliferation after binding to IL 2R on T cells. CD3AK cells utilize the combination of anti-CD3 monoclonal antibody with TCR / CD3 complex, while providing a small amount of exogenous IL2 to activate the cytotoxic effect of killer cells, commonly used in adoptive immunotherapy. Clinical funding