子宫内膜异位症是一种与雌激素水平密切相关的慢性炎症性疾病,好发于育龄期妇女,以导致痛经、盆腔疼痛以及不孕为主要临床特征[1]。手术治疗通常只能部分缓解症状,因此与其他慢性炎症性疾病一样,药物治疗是子宫内膜异位症的主要治疗方法[2]。随着相关研究的深入,子宫内膜异位症药物治疗有了比较大的进展。本文主要针对非激素药物治疗进行综述。1环氧化酶-2抑制剂环氧化酶(COX)又称前列腺素合成酶,是催化花生四烯酸 Endometriosis is a chronic inflammatory disease closely related to the level of estrogen. It occurs in women of childbearing age and leads to dysmenorrhea, pelvic pain and infertility as the main clinical features [1]. Surgical treatment usually only partially relieves the symptoms, so drug treatment, like other chronic inflammatory diseases, is the mainstay of endometriosis [2]. With the deepening of relevant research, there has been a great progress in the treatment of endometriosis. This article focuses on non-hormonal drug treatment review. 1 cyclooxygenase-2 inhibitor Cyclooxygenase (COX), also known as prostaglandin synthase, is a catalyst for arachidonic acid