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目的探究EV71-IgM与CA16-IgM对手足口病患儿病毒感染的诊断价值。方法应用酶联免疫吸附试验法测定223例手足口病患儿EV71-IgM与CA16-IgM。结果检出EV71-IgM 169例,占75.78%;CA16-IgM 156例,占69.96%;其他肠道病毒54例,占24.22%;患儿发病7、11 d内EV71-IgM、CA16-IgM检测阳性率分别为80.92%(140/173)、64.16%(111/173)和77.31%(167/216)、71.29%(154/216);发病第8天EV71-IgM检测阳性率下降至65.22%,CA16-IgM检测阳性率可达到100%;发病90 d后,EV71-IgM、CA16-IgM检测阳性率迅速下降,仅有1份血清可检测出。结论 EV71-IgM、CA16-IgM多见于手足口病患者病毒感染早期,可为其早期诊断提供重要依据。
Objective To investigate the diagnostic value of EV71-IgM and CA16-IgM in viral infections of hand-foot-mouth disease in children. Methods Enzyme-linked immunosorbent assay was used to determine the EV71-IgM and CA16-IgM in 223 HFMD children. RESULTS: 169 cases (75.78%) of EV71-IgM were detected, 156 cases of CA16-IgM (69.96%), 54 cases of other enterovirus (24.22%), EV71-IgM and CA16-IgM The positive rates were 80.92% (140/173), 64.16% (111/173), 77.31% (167/216) and 71.29% (154/216) respectively. On the 8th day, the positive rate of EV71-IgM decreased to 65.22% , The positive rate of CA16-IgM test can reach 100%. After 90 days, the positive rate of EV71-IgM and CA16-IgM decreased rapidly, and only one serum could be detected. Conclusion EV71-IgM and CA16-IgM are more common in HFMD patients at early stage of infection, which may provide an important basis for their early diagnosis.