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目的研究新疆维吾尔族及汉族胆固醇酯转运蛋白(CETP)-Taq IB基因多态性与新发心房颤动(AF)患者的相关性。方法 2013年1月至2016年1月在新疆医科大学第二附属医院新发AF患者111例,提取DNA,采用PCR-RFLP法对CETP-Taq IB进行基因型检测,比较基因型组间的差异。结果窦性心律组和新发AF组CETP-Taq IB的等位基因频率及基因型分布无明显差异(P﹥0.05)。将维吾尔族和汉族作为协变量分层,比较窦性心律组和新发AF组CETP-Taq IB的等位基因频率及基因型分布差异,结果显示维吾尔族、汉族CETP-Taq IB在窦性心律组和新发AF组中差异均无统计学意义(P﹥0.05),不同民族表达具有一致性。结论新疆维吾尔族及汉族CETP-Taq IB的等位基因频率及基因型分布与新发AF无相关性,无论在维吾尔族或汉族患者中均具有一致性,提示CETP-Taq IB可能不是新发AF的独立危险因素。
Objective To investigate the association of Xinjiang Uygur and Han cholesterol ester transfer protein (CETP) -Taq IB polymorphisms with newly diagnosed atrial fibrillation (AF) patients. Methods From January 2013 to January 2016, 111 newly diagnosed AF patients were recruited in the Second Affiliated Hospital of Xinjiang Medical University. DNA was extracted and the genotypes of CETP-Taq IB were detected by PCR-RFLP. The differences among genotype groups . Results There was no significant difference in allele frequency and genotype distribution between CETP-Taq IB and sinus rhythm group (P> 0.05). Uygur and Han were stratified as covariates. The allele frequency and genotype distribution of CETP-Taq IB in sinus rhythm group and new AF group were compared. The results showed that the frequency of CETP- There was no significant difference between the two groups (P> 0.05) and the new AF group (P> 0.05). Conclusion The allele frequencies and genotype distributions of CETP-Taq IB in Xinjiang Uygur and Han nationality have no correlation with newly diagnosed AF, which is consistent in both Uygur and Han patients, suggesting that CETP-Taq IB may not be a new-onset AF Of independent risk factors.