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本组在受致死照射和移植骨髓后活存小鼠的后期观察中曾发现,活存11个月的小鼠全部发生了不同程度的肝巨细胞包涵体病。已经确认,肝脏为移植物抗宿主反应的主要靶器官之一,而临床辐射事故或再障、白血病患者照后移植骨髓并发肝炎或肝脏巨细胞病毒感染的已屡有报导。然而,迄今有关照后移植骨髓患者肝脏并发病的动态变化尚不十分清楚,肝脏辐射损伤的远后效应尚未引起人们的重视。本文的目的即在观察照后移植骨髓小鼠并发肝巨细胞
This group in the late exposure to lethal irradiation and bone marrow survival after mice had found that all survived 11 months of mice had varying degrees of liver giant cell inclusion disease. It has been confirmed that the liver is one of the major target organs for graft-versus-host reaction, and clinical radiation accidents or aplastic anemia, leukemia patients with post-transplantation bone marrow complicated with hepatitis or cytomegalovirus infection have been reported frequently. However, to date, the dynamic changes of hepatic complications in post-transplant bone marrow are not yet clear, and far-reaching effects of liver damage have not drawn much attention. The purpose of this paper is to observe the transplantation of bone marrow cells in mice with liver giant cells