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目的观察一氧化氮抑制剂氨基胍对烫伤大鼠肌钙蛋白I的影响。方法Wistar大鼠60只,雌雄不拘,体重200±30 g,随机分为对照组(假伤组)、烫伤组和氨基胍组(烫伤前20分钟经腹腔内注入氨基胍40 mg/kg,余同烫伤组)。30%Ⅲ°TBSA烫伤,烫伤6小时后观测心脏功能、CTnI及血清NO水平的变化。结果烫伤后大鼠心脏舒缩功能明显下降,氨基胍抑制NO的形成加重了烫伤大鼠心肌损伤。结论氨基胍抑制NO生成加重了烫伤大鼠的心肌损害,提示NO对烧伤后早期心肌具有保护效应。
Objective To observe the effect of nitric oxide inhibitor aminoguanidine on troponin I in scalded rats. Methods Sixty Wistar rats, male and female, weighing 200 ± 30 g, were randomly divided into control group (sham injury group), scald group and aminoguanidine group (aminoguanidine 40 mg / kg 20 minutes before scald) With the burn group). 30% Ⅲ ° TBSA burns, burns 6 hours after the observation of cardiac function, CTnI and serum NO levels. Results After scald, the cardiac systolic and diastolic function of rats decreased obviously. The inhibition of nitric oxide by aminoguanidine aggravated the myocardial injury of scalded rats. Conclusion Aminoguanidine inhibits nitric oxide synthase (NO) production, which aggravates myocardial damage in scalded rats, suggesting that nitric oxide may have a protective effect on early postburn myocardium.