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本文旨在评价单剂量可乐定在国人颅脑外科手术中对异氟醚用量及围术期血流动力学的影响。２０例ＡＳＡⅠ－Ⅱ级颅脑择期手术病人随机分为两组。１组（对照组，ｎ＝１０）于术前３０ｍｉｎ给予阿托品０．５ｍｇ和苯巴比妥钠１０Ｏｍｇ肌注；Ⅱ组（可乐定组，ｎ＝１０）除１组术前用药外，另加可乐定５μｇ·ｋｇ－１于术前９０ｍｉｎ口眼。两组病人相比，可乐定组麻醉维持所需吸入、潮气末异氟醚浓度和异氟醚用量显著低于对照组（Ｐ＜０．０５），并且更能稳定麻醉诱导、置镜和插管过程中的血流动力学参数，具有一定的临床应用价值。
This article aims to evaluate the single dose of clonidine in Chinese craniocerebral surgery on the amount of isoflurane and perioperative hemodynamics. Twenty patients with ASA Ⅰ-Ⅱ stage brain elective surgery were randomly divided into two groups. Group 1 (control group, n = 10) received atropine 0.5 mg and phenobarbital 10O mg intramuscularly 30 min before operation; group Ⅱ (clonidine group, n = 10) Clonidine 5μg · kg-1 preoperative 90min mouth. Clopidogrel anesthesia compared with the two groups to maintain the required inhalation, end-tidal concentrations of isoflurane and the dosage of isoflurane was significantly lower than the control group (P <0.05), and more stable anesthesia induction, placement and insertion The process of hemodynamic parameters, has some clinical value.