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研究了２－氧代－２－氯－４－取代苯基－５，５－二甲基－１，３，２－二氧磷杂环己烷与３－羟基异 唑的反应，得到的氧磷酰化产物含有顺反两种异构体，用￣１ＨＮＭＲ、￣（３１）ＰＮＭＲ、Ｘ射线衍射确定了它们的构型，并讨论了亲核取代反应中手性磷原子构型保持和翻转的机理，测定了异构体的生物活性。
The reaction of 2-oxo-2-chloro-4-substituted phenyl-5,5-dimethyl-1,3,2-dioxaphosphorinane with 3-hydroxyisoxazole was studied and the resulting oxygen Phosphorylation products contain cis and trans isomers. Their configuration was confirmed by 1 H NMR, 31 P NMR and X-ray diffraction. The configuration of the chiral phosphorus atom in the nucleophilic substitution reaction was discussed. The biological activity of the isomers was determined.