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目的探讨焦炉逸散物接触对煤焦作业工人免疫调节因子的影响。方法采用职业卫生现场调查与实验室研究相结合的方法,测定作业环境中苯并(a)芘、苯溶物、焦炉逸散物等有害物质的质量浓度;选择91名焦炉作业工人作为接触组,80名无任何职业有害物质接触史的体检者作为对照组,采集空腹静脉血,用试剂盒检测血清中重要细胞免疫调节因子白细胞介素(IL)-2、IL-10、肿瘤坏死因子-α(TNF-α)的表达水平。结果焦炉作业工人工作场所存在职业有害因素,且炉顶有害物质质量浓度高于炉侧,存在职业有害因素;与对照组相比,焦炉作业工人血清IL-10、TNF-α水平均升高,IL-2水平则降低,差异有统计学意义(P<0.05)。在接触组中,炉顶工组、炉底工组IL-10、TNF-α高于炉侧工组,差异有统计学意义(P<0.05),IL-2水平差异无统计学意义(P>0.05)。焦炉作业工人血清IL-10与TNF-α水平及工作区域有害物质质量浓度之间呈正相关,IL-2水平及工作区域有害物质质量浓度之间呈负相关。结论本研究提示焦炉逸散物的接触可以引起体内免疫系统分泌的相应免疫调节因子IL-10、TNF-α水平升高,IL-2水平降低。IL-10、TNF-α水平升高与IL-2水平降低可以在一定程度上作为机体的焦炉逸散物接触程度的指标。
Objective To investigate the effect of coke oven exposure on the immunomodulatory factors of workers exposed to coal coke. Methods The method of combining occupational health field investigation and laboratory research was used to determine the mass concentration of harmful substances such as benzo (a) pyrene, benzene solubles and coke oven fugitives in the working environment. 91 coke oven workers Contact group and 80 subjects without history of exposure to occupational harmful substances as the control group. Fasting venous blood was collected and the serum cytokines IL-2, IL-10, tumor necrosis Factor-α (TNF-α) expression levels. Results There were occupational harmful factors in the workplace of coke oven workers, and the quality of harmful substances in the top of furnace was higher than that in the side of furnace. There were occupational harmful factors. Compared with the control group, the levels of IL-10 and TNF-α in coke oven workers increased High and IL-2 levels decreased, the difference was statistically significant (P <0.05). In the exposure group, the IL-10 and TNF-α in the top group and the bottom group were higher than those in the side group (P <0.05), but there was no significant difference in the IL-2 levels > 0.05). There was a positive correlation between serum IL-10 level and TNF-α level and the concentration of hazardous substances in the work area, and a negative correlation between IL-2 level and the concentration of harmful substances in the work area. Conclusions This study suggests that exposure of coke oven fume may cause the corresponding immune regulatory factors IL-10, TNF-α and IL-2 to be secreted by the immune system in vivo. IL-10, TNF-α levels and IL-2 levels can be reduced to some extent as an indicator of the extent of contact with coke oven fumes.