论文部分内容阅读
目的 :探索小肠移植膀胱后对不同剂量 N-丁基 - N- (4-羟基丁基 )亚硝胺 (N- butyl- N- (4- hydroxybutyl)nitrosam ine,BBN)诱发大鼠膀胱肿瘤的影响。方法 :空肠移植膀胱 (空肠组 ) ,回肠移植膀胱组 (回肠组 ) ,未手术组(对照组 )进行不同剂量 BBN诱发膀胱肿瘤实验。低剂量 BBN给药群共 9只 ,其中回肠组 5只 ,对照组 4只 ;高剂量BBN给药群共 17只 ,其中空肠组 5只 ,回肠组 6只 ,对照组 6只。结果 :所有移植到膀胱上的小肠段除空肠组 1只外 ,均未发生肿瘤 ;所有大鼠膀胱组织均有肿瘤发生 ,但手术组肿瘤分化程度较好。结论 :小肠与膀胱组合后对 BBN诱发大鼠膀胱肿瘤有抑制倾向 ,这种倾向在高、低剂量 BBN群之间无明显差异
OBJECTIVE: To explore the effects of different doses of N-butyl-N- (4-hydroxybutyl) nitrosamine (BBN) on bladder tumor in small intestine influences. Methods: Bladder tumor was induced by different doses of BBN in the jejunal transplantation bladder (jejunum group), ileum transplantion bladder group (ileum group), and non-surgical group (control group). A total of 9 low-dose BBN groups were given, including 5 in the ileum group and 4 in the control group. There were 17 high-dose BBN-administered groups, including 5 in the jejunum group, 6 in the ileum group, and 6 in the control group. Results: All of the small intestine segments transplanted to the bladder had no tumor except one in the jejunum group. All of the bladder tissues of the rats had tumors, but the degree of tumor differentiation in the operation group was better. CONCLUSIONS: Intestinal small bowel combined with bladder can inhibit BBN-induced bladder tumor in rats. This tendency has no significant difference between high and low dose BBN groups