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目的探讨Gli-1蛋白在胃癌组织中的表达情况及临床意义。方法应用免疫组化SP法检测65例胃癌组织及16例癌旁正常组织中Gli-1蛋白的表达,并结合患者的临床资料进行分析。结果在胃癌组织中Gli-1蛋白阳性表达率为64.5%(40/62),高于相应正常组织的0(0/16),差异有统计学意义(P=0.000)。Gli-1蛋白阳性表达率与胃癌患者的不同组织学分级、临床分期和淋巴结转移状态间的差异具有统计学意义(P<0.05)。结论 Gli-1可能在胃癌的进展中起重要作用,其蛋白表达可以作为一项临床诊断的重要指标。
Objective To investigate the expression of Gli-1 protein in gastric carcinoma and its clinical significance. Methods The expression of Gli-1 protein in 65 cases of gastric cancer tissues and 16 cases of adjacent normal tissues was detected by immunohistochemical SP method and analyzed with the clinical data of patients. Results The positive rate of Gli-1 protein in gastric cancer tissues was 64.5% (40/62), which was significantly higher than that of corresponding normal tissues (0/16) (P = 0.000). The positive rate of Gli-1 protein was significantly different from that of gastric cancer patients in different histological grade, clinical stage and lymph node metastasis (P <0.05). Conclusion Gli-1 may play an important role in the progression of gastric cancer, and its expression may serve as an important indicator of clinical diagnosis.