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目的 探讨大肠癌中nm2 3 H1的表达与淋巴转移的关系。方法 应用免疫组化方法研究 96例大肠癌中nm2 3 H1蛋白的表达。结果 nm2 3 H1蛋白低表达与淋巴结或远处转移显著相关 (P <0 0 5) ;nm2 3 H1蛋白低表达预测大肠癌转移的灵敏性为 88 4 % ,特异性为 79 3%。结论 检测nm2 3 H1蛋白可以预测大肠癌淋巴结或远处转移 ,从而可能成为临床治疗的判断依据。
Objective To investigate the relationship between the expression of nm23 H1 in colorectal carcinoma and lymphatic metastasis. Methods The expression of nm23 protein in 96 cases of colorectal cancer was studied by immunohistochemistry. Results The low expression of nm23 protein was associated with lymph node or distant metastasis (P <0.05). The low expression of nm23 protein predicted 88 4% and 79 3% of the metastasis of colorectal carcinoma. Conclusion The detection of nm23 H1 protein can predict the lymph node metastasis of colorectal cancer, which may become the basis for clinical treatment.