目的分析幕上胶质瘤伴发癫痫的临床特点及两者之间的相关性。方法回顾性分析我院自2000年1月至2006年12月收治的51例以癫痫为首发症状或主要症状的幕上胶质瘤患者的临床资料。结果51例患者中有50例行开颅手术,术后病理检查证实,星形细胞瘤Ⅰ级23例,Ⅱ级18例,Ⅲ-Ⅳ级9例。术后所有病例均继续服抗癫痫药物治疗,癫痫基本得到控制。结论以癫痫为首发症状或主要症状的胶质瘤以低级别的较多,外科治疗效果较好;胶质瘤引起的周围水肿和牵拉效应可能是继发癫痫的病因。 Objective To analyze the clinical characteristics of supratentorial glioma with epilepsy and the correlation between them. Methods The clinical data of 51 patients with supratentorial glioma who had epilepsy as the first symptom or main symptom were retrospectively analyzed in our hospital from January 2000 to December 2006. Results Fifty-one of 51 patients underwent craniotomy. Pathological examination confirmed that astrocytoma was grade Ⅰ in 23 cases, grade Ⅱ in 18 cases, and grade Ⅲ-Ⅳ in 9 cases. After all cases continue to take antiepileptic drugs, epilepsy basic control. Conclusion Epilepsy as the first symptom or main symptom of glioma with low-level more, surgical treatment is better; glioma-induced peripheral edema and traction effect may be the cause of secondary epilepsy.