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Dew 等人用5-ASA 治疗溃疡性结肠炎获得了成功的经验,15例患者中有11例以前不能耐受柳氮磺胺嘧啶治疗,改用5-ASA 治疗有效。然而,其中2例有严重副作用,与以前用柳氮磺胺嘧啶所致的腹泻、腹痛相似。例1 17岁,男孩,诊断为溃疡性结肠炎,用柳氮磺胺嘧啶治疗,2周内四肢出现出血性疱疹伴呕吐、发热、腹泻而停药,症状渐减轻。为减少复发而用5-ASA,5天后四肢疼痛、腹痛、腹泻、呕吐、发烧39℃,前臂出现斑丘疹。停用5-ASA,全部副作用在48小时内消失。
Dew et al. Obtained successful experience with 5-ASA in the treatment of ulcerative colitis. Previously, 15 of 15 patients were refractory to sulfasalazine and 5-ASA. However, two of these patients had serious side effects similar to the previous diarrhea and abdominal pain caused by sulfasalazine. Example 1 A 17-year-old boy diagnosed with ulcerative colitis treated with sulfasalazine developed symptoms of hemorrhagic herpes with vomiting, fever and diarrhea within two weeks. 5-ASA was used to reduce recurrence, 5 days after limb pain, abdominal pain, diarrhea, vomiting, fever 39 ℃, forearm rash. With 5-ASA disabled, all side effects disappeared within 48 hours.