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抗心律失常药物引起心律失常在临床上表现形式有二种,即缓慢型心律失常和快速型心律失常。 1.缓慢型心律失常 包括窦性心动过缓,窦房阻滞、窦性静止、房室传导导阻滞等。抗快速型心律失常药都可能诱发缓慢型心律失常,如Ⅰ类(钠通道阻滞剂)、Ⅱ类(β-受体阻滞剂)、Ⅳ类(钙拮抗剂)抗心律失常药及洋地黄可引起极度窦性动过缓或窦性静止,大剂量或高浓度时可引起房室传导阻滞,原有房室传导延迟者,当使用奎尼丁、普鲁卡因酰胺、丙吡胺、氟卡胺或思卡胺等药物时,可发生高度房室传导阻滞。
Antiarrhythmic drugs cause arrhythmias There are two clinical manifestations, namely, slow arrhythmia and tachyarrhythmia. 1. Slow arrhythmia, including sinus bradycardia, sinus block, sinus rest, atrioventricular block and so on. Antiarrhythmic drugs may induce slow arrhythmias such as class I (sodium channel blockers), class II (β-blockers), class IV (calcium antagonists) antiarrhythmic drugs and foreign Rehmannia can cause extreme sinus bradycardia or sinus quiescence, high dose or high concentration can cause atrioventricular block, the original delay of atrioventricular conduction, when using quinidine, procainamide, Amine, flecainide, or simvastatin and other drugs, can occur in a high degree of atrioventricular block.