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目的分析Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、层粘连蛋白(LN)和透明质酸酶(HA)在诊断肝纤维化程度的作用。方法采用化学发光法测定120例病毒性肝炎患者及80例健康献血者血清PCⅢ、Ⅳ-C、LN和HA水平,结合病理结果分析其与肝纤维化程度的关系。结果上述四项血清学指标在肝炎患者中均明显升高,以肝硬化者为最高,其升高程度与肝纤维化及肝病严重程度呈正相关。结论血清PCⅢ、Ⅳ-C、LN和HA水平与肝纤维化程度相关,可作为反映慢性肝病肝纤维化严重程度和预后的指标。
Objective To analyze the role of PC Ⅲ, Ⅳ-C, LN and HA in the diagnosis of liver fibrosis. Methods The levels of PCⅢ, Ⅳ-C, LN and HA in serum of 120 patients with viral hepatitis and 80 healthy donors were determined by chemiluminescence method. The relationship between the levels of PCⅢ, Ⅳ-C, LN and HA was analyzed by pathological results. Results The above four serological indicators were significantly elevated in patients with hepatitis, cirrhosis were the highest, the degree of increase was positively correlated with the severity of liver fibrosis and liver disease. Conclusions The serum levels of PCⅢ, Ⅳ-C, LN and HA are correlated with the degree of liver fibrosis and can be used as an index to reflect the severity and prognosis of chronic liver disease.