使用大剂量(总量在200mg以上)的青霉素,可致一种罕见的、严重的、但可逆的白细胞减少和嗜中性细胞减少综合征。目前,尚不能肯定这种白细胞减少是毒性的作用还是免疫所致。作者报导了采用新鲜青霉素快速静脉给药的两位白细胞减少患者。一位是患有二尖瓣闭锁不全和有葡萄球菌心内膜炎的35岁男性患者,用快速静脉滴注(每次20分钟以上,经灌注器输入),其 The use of large doses (200 mg total) of penicillin results in a rare, severe but reversible leukopenia and neutropenic syndrome. At present, it is not yet certain whether this leukopenia is toxic or immune. The authors report two patients with leucopenia who were rapidly iv administered with fresh penicillin. One was a 35-year-old man with mitral regurgitation and staphylococcal endocarditis who was treated with rapid intravenous drip (more than 20 minutes each via syringe)