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研究辐射对红细胞酶损伤的远后效应。方法对５例骨髓型急性放射病病人受照后第１，２，３，６年分别进行五大类代谢途径８种红细胞酶活力动态观察。结果受照后初期活力低下的酶Ｇ６ＰＤ、ＰＫ、ＭＲ及恢复期活力下降的酶ＡＣＥ在后续４次测定中均有不同程度回升，但个别患者的上述前三种酶活力始终低于正常下限。受照剂量、患者年龄与酶活力变化之间无显著相关性。结论辐射对红细胞酶损伤的远后效应在糖酵解酶ＰＫ、已糖旁路酶Ｇ６ＰＤ和氧化还原代谢酶ＭＲ表现最为明显。结果提示，辐射可能损伤了参与酶合成的相关基因
Far-reaching effects of radiation on erythrocyte enzyme damage were studied. Methods The activity of 8 kinds of erythrocytes in five kinds of metabolic pathways of five kinds of patients with acute myeloid leukemia were dynamically observed in the first, second, third and sixth year after irradiation. Results The initial low activity of enzyme G6PD, PK, MR and the decreased activity of enzyme ACE during recovery were all increased to some extent in the following four tests. However, the activity of the first three enzymes of individual patients was always below the lower limit of normal. There was no significant correlation between exposure dose, patient age and changes in enzyme activity. Conclusion The far-reaching effect of radiation on erythrocyte enzyme damage is most obvious in the glycolytic enzyme PK, hexose sugar-metabolizing enzyme G6PD and redox metabolizing enzyme MR. The results suggest that radiation may damage the genes involved in enzyme synthesis