H_2受体拮抗剂能有效地降低胃酸的分泌,是治疗消化性溃疡和卓一艾综合征的有效药物.引外尚可用于急性胃肠道出血、胃食道返流、胃炎、胰腺功能不全的治疗,还可预防应激性溃疡和麻醉引起的肺酸吸入综合征.这类药物广泛用于临床,且常与其他药物合用.因此,H_2受体拮抗剂与心血管药物合用时可能发生相互作用.西米替丁和雷尼替丁与其他药物相互作用有以下几种机理:(1)抑制肝脏微粒体酶,使肝脏民P_(450)对药物的代谢作用减弱;(2)降低肝血流量,使肝脏摄取率高的药物廓清率减低;(3) 两种药物 H 2 receptor antagonists can effectively reduce gastric acid secretion, is an effective drug for the treatment of peptic ulcer and Zhuoyi Ai syndrome. Induction can be used for acute gastrointestinal bleeding, gastroesophageal reflux, gastritis, pancreatic insufficiency Treatment, but also to prevent stress ulcer and narcosis caused by pulmonary aspiration syndrome. These drugs are widely used in clinical and often combined with other drugs, therefore, H 2 receptor antagonist and cardiovascular drugs may occur when combined Effect of cimetidine and ranitidine interaction with other drugs have the following mechanisms: (1) inhibition of liver microsomal enzymes, so that the liver P45 (450) on the metabolism of drugs weakened; (2) reduce the liver Blood flow, so that the liver uptake rate of drug clearance rate is reduced; (3) two drugs