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目的 研究p16和 p2 7在乳腺癌中的表达并探讨其对预后的意义。方法 对 84例乳腺癌、2 0例乳腺不典型增生以及 2 0例正常乳腺组织进行 p16和p2 7表达的的检测并分析其结果。结果 乳腺癌组 p16阳性率和p2 7高表达率均明显高于对照组 (P <0 .0 5 )。p16表达与淋巴结转移、临床分期相关 (P <0 .0 5 )。p2 7表达与淋巴结转移、临床分期、局部复发和远处转移相关 (P <0 .0 5 )。p16阳性患者术后生存率明显高于p16阴性者 (P <0 .0 5 )。p2 7高表达的乳腺癌术后生存率明显高于 p2 7低表达者 (P <0 .0 5 )。p16在乳腺癌中的表达与 p2 7的表达相关 (P <0 .0 1)。p16阳性并且同时有 p2 7高表达的乳腺癌术后生存率明显高于p16阴性并且同时 p2 7低表达者 (P <0 .0 5 ) ,但与单独p16阳性或单独 p2 7高表达者相比无显著差异 (P <0 .0 5 )。结论 乳腺癌组的 p16阳性率和p2 7高表达率明显高于对照组 ;p16阳性、p2 7高表达的乳腺癌患者预后好 ;p16、p2 7都是乳腺癌独立的预后因子
Objective To study the expression of p16 and p27 in breast cancer and to explore its significance on prognosis. Methods The expression of p16 and p27 in 84 cases of breast cancer, 20 atypical hyperplasia of mammary gland and 20 cases of normal breast tissue were detected and analyzed. Results The positive rates of p16 and p27 in breast cancer were significantly higher than those in control group (P <0.05). The expression of p16 was correlated with lymph node metastasis and clinical stage (P <0.05). The expression of p27 was correlated with lymph node metastasis, clinical stage, local recurrence and distant metastasis (P <0.05). The postoperative survival rate of p16-positive patients was significantly higher than that of p16-negative patients (P <0.05). The postoperative survival rate of p27-overexpressed breast cancer was significantly higher than that of p27-low overexpression (P <0.05). The expression of p16 in breast cancer correlated with the expression of p27 (P <0.01). The postoperative survival rate of p16-positive breast cancer with p27 expression was significantly higher than that of p16-negative and p27 low expression (P <0.05), but not with p16-positive or p27- No significant difference (P <0.05). Conclusion The positive rates of p16 and p27 in breast cancer patients were significantly higher than those in the control group. The positive rates of p16 and p27 in patients with breast cancer were high, and p16 and p27 were independent prognostic factors in breast cancer