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阴茎海绵体平滑肌小梁和海绵窦松弛在勃起过程中起关键作用,其详细机制有待进一步阐明。上述组织具有丰富的肾上腺素能神经和胆碱能神经,传统认为阴茎勃起是副交感神经反应,但近年来发现乙酰胆碱并不是唯一的节后副交感神经递质。血管活性肠肽(VIP)、降钙素基因相关肽(CGRP)、神经肽Y(NPY)以及P物质(SP)等均有可能作为递质参与勃起过程。本文拟就这类非肾上腺素能、非胆碱能物质与阴茎勃起组织的关系作一综述。 VIP VIP为28肽,1970年由Said和Mutt从猪小肠粘膜分离出,能扩张血管,松弛平滑肌。VIP分布很广,尤以消化道、生殖道、呼吸道为多。中枢和外周血管有VIP纤维支配,可能调节局部血流。VIP参与外周自主神经系统的反射功能。外周支配腺体
Cavernous smooth muscle trabecular and cavernous sinus relaxation play a key role in the erectile process, the detailed mechanism to be further elucidated. These tissues are rich in adrenergic and cholinergic nerves, the penis erection is traditionally thought to be a parasympathetic response, but in recent years, acetylcholine is not found as the only postganglionic parasympathetic neurotransmitter. Vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), neuropeptide Y (NPY), and substance P (SP) may participate in the erectile process as a transmitter. This article intends to review the relationship between non-adrenergic and non-cholinergic substances and penile erection. The VIP VIP is a peptide of 28 and was isolated from the small intestine mucosa by Said and Mutt in 1970 to dilate the blood vessels and relax the smooth muscle. VIP distribution is very wide, especially in the digestive tract, genital tract, respiratory tract and more. Central and peripheral vessels have VIP fiber control, may regulate local blood flow. VIP participates in the reflex function of peripheral autonomic nervous system. Peripheral dominates the gland