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目的 比较SIVmac感染的食蟹猴、恒河猴外周血粒系统变化情况。方法 常规方法进行白细胞 (WBC)和白细胞分类计数 (WBC .DC)。结果 感染了SIVmac的恒河猴、食蟹猴其外周血粒系统变化与人类AIDS外周血变化相似 ,显现规律性的白细胞数量、形态变化。感染SIVmac病毒两周后 ,恒河猴、食蟹猴的白细胞总数开始下降 ,异型淋巴细胞数开始上升 ,随后白细胞总数持续回升至高峰 ,8周后白细胞总数及异型淋巴细胞数下降 ,其中三只食蟹猴先后于 8周后死于病毒血症和早期死亡 ,余 1只猴白细胞总数于 12周后仍持续下降。结论 本文中描述的现象同人类HIV AIDS的诊断标准实验检查部分中提及的基本一致。另外 ,本实验还表明恒河猴、食蟹猴对SIVmac毒株的实验感染是敏感的 ,食蟹猴对SIVmac更敏感
Objective To compare the systemic changes of peripheral blood monkeys in SIVmac-infected cynomolgus monkeys. Methods The white blood cell (WBC) and white blood cell count (WBC. DC) were routinely performed. The results of systemic infection of SIVmac rhesus monkey, cynomolgus monkey peripheral blood system changes and human AIDS peripheral blood changes similar to the regular white blood cells showed the number of morphological changes. After two weeks of infection with SIVmac virus, the total number of white blood cells in rhesus monkey and cynomolgus monkey began to decrease, the number of atypical lymphocytes began to rise, and then the total number of leukocytes continued to rise to its peak. After 8 weeks, the total number of white blood cells and atypical lymphocytes decreased, of which three Cynomolgus died of viremia and early death after 8 weeks, while the remaining 1 monkey leucocyte continued to decline after 12 weeks. Conclusions The phenomena described in this article are basically the same as those mentioned in the Experimental Checks for Diagnostic Criteria of Human HIV / AIDS. In addition, this experiment also showed that rhesus monkeys and cynomolgus monkeys were susceptible to experimental infection with SIVmac strains, while cynomolgus monkeys were more susceptible to SIVmac