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目的探讨乙型病毒性肝炎患者发生血小板减少症的危险因素。方法应用自制调查问卷,对127例乙型病毒性肝炎患者进行调查,描述性统计和二分类logistic回归分析乙型病毒性肝炎患者发生血小板减少症的因素。结果 127例患者血小板减少症发生率为29.92%(38/127),其中Ⅰ度血小板减少21例。多因素logistic回归分析显示肝功能损害程度(OR=12.99,P=0.000)、肝硬化(OR=8.68,P=0.000)、脾脏大(OR=7.73,P=0.000)、乙型肝炎病毒DNA水平(OR=18.79,P=0.000)、血小板相关免疫球蛋白水平(OR=5.52,P=0.000)、合并丙型肝炎感染(OR=6.20,P=0.000)是乙型病毒性肝炎患者出现血小板减少症的危险因素。结论乙型病毒性肝炎患者血小板减少症发生率较高,其发生受多方面因素的影响。
Objective To investigate the risk factors of thrombocytopenia in patients with viral hepatitis B Methods Using self - made questionnaire, 127 cases of hepatitis B patients were investigated, descriptive statistics and binary logistic regression analysis of patients with viral hepatitis B thrombocytopenia. Results The incidence of thrombocytopenia in 127 patients was 29.92% (38/127), with grade Ⅰ thrombocytopenia in 21 cases. Multivariate logistic regression analysis showed that liver damage (OR = 12.99, P = 0.000), cirrhosis (OR = 8.68, P = 0.000), splenomegaly (OR = 7.73, P = 0.000), hepatitis B virus DNA level (OR = 18.79, P = 0.000), platelet-associated immunoglobulin (OR = 5.52, P = 0.000), and hepatitis C infection (OR = 6.20, P = 0.000) Disease risk factors. Conclusion The incidence of thrombocytopenia in patients with viral hepatitis B is high, and its occurrence is affected by many factors.