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ＭＤＲ(多药耐药 )基因及其编码的Ｐ 糖蛋白与多重耐药及抗性肿瘤细胞发生发展有关 ,Ｐ 糖蛋白是一种ＡＴＰ 依赖泵 ,主要的生理功能是减少细胞内药物蓄积 ,增加抗性肿瘤细胞的数目[1] 。随着对Ｐ 糖蛋白其他多种生理功能的研究 ,Ｐ 糖蛋白在药动学及药效学方面的调节作用得到
The MDR (multidrug resistance) gene and its encoded P glycoprotein are involved in the development of multidrug resistant and resistant tumor cells. P glycoprotein is an ATP dependent pump whose main physiological function is to reduce intracellular drug accumulation and increase The number of resistant tumor cells [1]. With the study of various other physiological functions of P-glycoprotein, the regulation of P-glycoprotein in pharmacokinetics and pharmacodynamics