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【目的】探讨联合检测CEA、AFP、CA-125、CA-199等肿瘤标志物对胃癌术后复发的诊断价值。【方法】观察了118例胃癌患者,皆行胃癌根治手术或姑息手术,其中追踪观察到46例患者术后胃癌复发或发生转移癌,25例未发生胃癌复发或转移癌。分别于术前、术后与复发(复诊)后联合检测CEA、AFP、CA-125、CA-199等肿瘤标志物,对比观察术前、术后与复发后CEA、AFP、CA-125、CA-199等肿瘤标志物的特点。【结果】术后各项肿瘤标志物水平均明显下降;复发病例各项肿瘤标志物水平则明显上升,甚至高于术前水平。转移癌肿瘤标志物水平均明显高于残胃癌。CA-199与CA-125联检阳性者76.8%确诊为胃癌复发或发生转移癌;CEA、CA-199与CA-125联检均为阳性者91.9%确诊为胃癌复发或发生转移癌;CEA、AFP、CA-199与CA-125四项联检均为阳性者95.5%确诊为胃癌复发或发生转移癌。【结论】CEA、AFP、CA-125、CA-199等联合检验对提高肿瘤标志物对胃癌术后的临床诊断价值具有重要的意义,值得推广应用。
【Objective】 To explore the diagnostic value of combined detection of tumor markers such as CEA, AFP, CA-125 and CA-199 in the postoperative recurrence of gastric cancer. 【Methods】 A total of 118 patients with gastric cancer underwent radical surgery or palliative surgery. Gastric cancer recurrence or metastasis was observed in 46 patients, and no recurrence or metastasis of gastric cancer occurred in 25 patients. CEA, AFP, CA-125, CA-199 and other tumor markers were detected preoperatively, postoperatively and after relapse (referral) respectively. CEA, AFP, CA-125, CA -199 and other tumor markers. 【Results】 The levels of various tumor markers decreased significantly after operation. The levels of all tumor markers in the recurrent cases increased significantly, even higher than preoperative levels. Metastatic cancer tumor markers were significantly higher than the residual gastric cancer. The positive rates of CEA, CA-199 and CA-125 were 91.8%, and the positive rates of CEA, AFP, CA-199 and CA-125 were 76.8% CA-199 and CA-125 four joint test were positive 95.5% were diagnosed as gastric cancer recurrence or metastatic cancer. 【Conclusion】 The combined tests of CEA, AFP, CA-125 and CA-199 are of great significance to improve the clinical diagnostic value of tumor markers for postoperative gastric cancer, which is worth to be popularized and applied.