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目前在胃溃疡和十二指肠溃疡发病学的认识上与以往不同,胃溃疡的主要因素是胆汁逆流,而十二指肠溃疡是由于迷走神经功能亢进,过多胃酸进入十二指肠,致使消化粘膜成为溃疡。组织胺是强烈的胃酸分泌刺激剂,小量可明显促进胃蛋白酶和胃酸分泌。因此,对十二指肠溃疡,组织胺具有一定作用。近年合成的甲氰咪胺(胍)具有阻断组织胺H_2-受体的作用,可抑制胃酸分泌,是治疗十二指肠溃疡较理想的药物。国产甲氰咪胍首先由重庆医药工业研究所试制成功,并于1978年11月用于临床。大量临床资料证实,甲氰咪胍是一种有效的组织胺H_2一受体拮抗
Currently in the understanding of the pathogenesis of gastric ulcer and duodenal ulcer different from the past, the main factor of gastric ulcer is bile reflux, and duodenal ulcer is due to vagal hyperactivity, excessive gastric acid into the duodenum, resulting in Digestive mucosa becomes ulcer. Histamine is a strong gastric acid secretion stimulator, a small amount can significantly promote pepsin and gastric acid secretion. Therefore, duodenal ulcer, histamine has a certain effect. In recent years, the synthesized mecamylamine (guanidine) has the effect of blocking the histamine H 2 -receptor and can inhibit gastric acid secretion, which is an ideal drug for the treatment of duodenal ulcer. Domestic cimetidine first trial by the Chongqing Institute of Pharmaceutical Industry trial, and in November 1978 for clinical use. A large number of clinical data confirm that cimetidine is a potent histamine H 2 -receptor antagonist