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最近在人类非小细胞肺癌研究中发现定位于染色体11q23.2上一种新的肿瘤抑制因子TSLC1(tumor suppressor in lung cancer1),编码属于Nectin分子的类似免疫球蛋白超家族的细胞表面跨膜糖蛋白Nec1-2,其细胞外结构与其他免疫球蛋白超家族细胞黏附分子高度同源。由于启动子甲基化和
Recently a novel tumor suppressor in lung cancer 1 located on chromosome 11q23.2 was found in human non-small cell lung cancer studies that encode cell surface transmembrane glycans that are similar to the immunoglobulin superfamily of nectin molecules The protein Nec1-2, whose extracellular structure is highly homologous to other immunoglobulin superfamily cell adhesion molecules. Due to promoter methylation and