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目的 :评价奥沙利铂、5 氟尿嘧啶、甲酰四氢叶酸联合化疗治疗晚期大肠癌的疗效及毒副反应。方法 :本组晚期大肠癌患者共 3 8例 ,以奥沙利铂 85mg/m2 静脉点滴 2h第 1天 ,甲酰四氢叶酸 (CF) 2 0 0mg/m2 静脉点滴第 1、2天 ,5 氟尿嘧啶 (5 FU) 40 0mg/m2 静脉推注第 1、2天 ,5 FU 60 0mg/m2 静脉点滴 2 2h ,第 1、2天。每 2周重复 ,4周期后评定疗效。结果 :3 8例中CR 2例 ,PR 14例 ,SD16例 ,PD 6例 ,总有效率 (CR +PR) 42 %。主要毒副反应为神经系统毒性、胃肠道反应、骨髓抑制、黏膜炎等。除 2例出现Ⅲ度神经系统毒性外 ,其余毒副反应均为Ⅰ～Ⅱ度。结论 :奥沙利铂联合氟尿嘧啶、甲酰四氢叶酸治疗晚期大肠癌疗效较好 ,毒副反应轻 ,值得临床进一步研究推广。
Objective: To evaluate the efficacy and toxicity of oxaliplatin, 5-fluorouracil and leucovorin in the treatment of advanced colorectal cancer. METHODS: A total of 38 patients with advanced colorectal cancer in this group were treated with oxaliplatin 85 mg/m2 intravenously for 2 hours on the 1st day. Formyl tetrahydrofolate (CF) 200 mg/m2 intravenously on the 1st and 2nd days. 5 Fluorouracil (5 FU) 400 mg/m2 intravenous injection on the 1st and 2nd days, 5 FU 60 0mg/m2 intravenous drip 2 2h, the first 1 and 2 days. Repeat every 2 weeks and evaluate the curative effect after 4 cycles. Results: Of the 38 cases, 2 were CR, 14 were PR, 16 were SD, and 6 were PD. The total effective rate (CR +PR) was 42%. The main toxicities were neurotoxicity, gastrointestinal reactions, bone marrow suppression, and mucositis. Except for 2 cases of grade III neurotoxicity, the other toxicities were I to II degrees. Conclusion :Oxaliplatin combined with fluorouracil and leucovorin has good curative effect on advanced colorectal cancer, and has mild side effects. It is worthy of further clinical research and promotion.