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本文采用微核试验方法对维生素Ｅ（ＶｉｔＥ）拮抗氯化汞（ＨｇＣｌ２）致小鼠胸骨骨髓多染红细胞微核作用进行了研究。其主要结果有：（１）给小鼠ＶｉｔＥ５ｍｇ／ｋｇ体重及以上剂量时，可显著地降低ＨｇＣｌ２１．０ｍｇ／ｋｇ体重的致小鼠微核作用（Ｐ＜０．００１）；（２）在ＨｇＣｌ２（１．０ｍｇ／ｋｇ）给小鼠染毒前４ｈ和染毒后２ｈ内补充ＶｉｔＥ２０ｍｇ／ｋｇ体重时，均显示明显地拮抗致微核作用（Ｐ＜０．００１～Ｐ＜０．０１）；（３）隔日给小鼠ＶｉｔＥ２．５ｍｇ／ｋｇ体重一个月后也可显著地减少ＨｇＣｌ２（１．０ｍｇ／ｋｇ）的致微核作用（Ｐ＜０．００１）。
In this paper, micronucleus test was used to study the effect of vitamin E on the micronuclei of erythrocytes in sternal bone marrow of mice induced by mercury chloride (HgCl2). The main results were as follows: (1) The micronuclei of mice induced by HgCl21.0mg / kg body weight were significantly decreased (P <0.001) when mice were given VitE5mg / kg body weight and above; (2) (1.0 mg / kg), 4 h before exposure to mice and 20 mg / kg of VitE supplemented within 2 h after exposure, all showed significant antagonism of micronuclei (P <0.001 ~ P <0.01). (3) The micronucleus effect of HgCl2 (1.0 mg / kg) was also significantly reduced (P <0.001) one month after VitE 2.5 mg / kg body weight was administered to mice on alternate days.