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目的:探讨汉族急性心肌梗死患者DNaseI基因A2317G位点的基因型及与血脂、血糖的关系。方法:应用PcR-LoR法分析汉族急性心肌梗死患者DNaseI基因多态性,计算各基因型分布频率,不同基因型与空腹血糖、血脂的相关性。采用sAs软件进行统计分析。结果:汉族AMI患者中DNA酶摹基因A2317G位点基因型和等位基因频率分布符合Hardy-weinberg平衡定律,A2317G位点等位基因频率分别为0.52、0.48,不同基因型的血酯、血糖水平差异无统计学意义(P>0.05)。结论:AMI患者中A2317G位点等位基因频率与与亚洲人群中的蒙古人、日本人相似,而与韩国人、土耳其人、纳米比亚人和德国人明显不同,DNaseI基因多态性具有显著的种族异质性。
Objective: To investigate the genotype of DNaseI gene A2317G in patients with acute myocardial infarction and its relationship with blood lipid and blood glucose. Methods: The polymorphism of DNaseI gene in patients with acute myocardial infarction was analyzed by PcR-LoR method. The correlation between genotype distribution frequency, different genotypes and fasting blood glucose and blood lipid was calculated. Using sAs software for statistical analysis. Results: The genotypes and alleles of A2317G allele in Han nationality AMI matched with Hardy-weinberg equilibrium. The frequencies of A2317G allele were 0.52 and 0.48, respectively. The blood glucose and blood glucose levels of different genotypes The difference was not statistically significant (P> 0.05). CONCLUSIONS: The frequency of allele A2317G in AMI patients is similar to that of Mongoloid and Japanese in Asian populations, but significantly different from Koreans, Turks, Namibians and Germans, and the DNaseI gene polymorphism has significant ethnicity Heterogeneity.