人类周围神经损伤后,由于神经再生距离较长、再生速度较慢,长时间后往往在损伤远侧段发生由轴突溃变导致的一系列改变,称之为慢性失神经(chronic denervation)。慢性失神经不仅涉及远侧段神经,还会影响所支配的肌肉和皮肤以及近侧段神经,导致损伤后神经修复失败,伤者的感觉和运动功能恢复不理想,有的还会出现神经病理性痛。因此, Human peripheral nerve injury, due to the longer nerve regeneration, slow regeneration, often after a long time in the distal segment of the injury caused by a series of changes in axonal degeneration, called chronic denervation. Chronic denervation involves not only the distal segment nerves but also the innervated muscles and skin and the proximal segment nerves, resulting in failure of the nerve repair after injury, loss of sensory and motor function recovery, and neuropathology pain. therefore,