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探讨内皮素(ET)与肝硬变水纳潴溜的关系。方法:应用放免法测定了血浆内皮素(ET)和心纳素(ANP)的含量。结果:①68例肝硬变患者血浆ET水平与正常人相比明显低下(P<0.01),按Child-Pugh分级,可见ET在伴腹水的患者下降明显(B、C级);②ET与门静脉直径呈负相关(r=-0.769,P<0.05),门静脉直径>1.6cm者与直径<1.6cm者相比,ET含量差异亦有显著性意义(P<0.01);③肝硬变患者ANP值明显高于正常对照组(P<0.01),且ANP与ET水平呈负相关(r=-0.786,P<0.01)。结论:ET水平与肝硬变严重程度密切相关,ET可能在腹水形成机制中发挥了重要作
To investigate the relationship between endothelin (ET) and liver cirrhosis. Methods: The contents of plasma ET and ANP were determined by radioimmunoassay. Results: ①The plasma ET level of 68 patients with cirrhosis was significantly lower than that of the normal people (P <0.01). According to Child-Pugh classification, ET patients with ascites decreased significantly (B, C); ②ET and portal vein diameter (R = -0.769, P <0.05). There was also a significant difference in ET content between portal vein diameter> 1.6cm and diameter <1.6cm (P <0.01). ③The ANP value (P <0.01), and negatively correlated with ET level (r = -0.786, P <0.01). Conclusion: The level of ET is closely related to the severity of liver cirrhosis. ET may play an important role in the mechanism of ascites formation