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为探讨炔诺孕酮（１８甲）药尘对生产工人健康的影响，调查并测定了我国生产１８甲的两个原料药厂车间空气中总粉尘平均浓度为６．３５ｍｇ／ｍ３。３１名生产人员（女２２，男９）主要在嗜睡、恶心及女工的月经失调、经间期点滴出血以及肝功异常、血糖升高等临床改变与对照组差异显著。当其脱离接触１８甲两个月后，近半数人血药浓度恢复正常，症状大部消失；但仍有半数以上人员血药水平平均在５３８ｐｍｏｌ／Ｌ，并伴有某些症状。当再上岗生产１８甲３个月后，血药浓度坪值水平平均在２５８４ｐｍｏｌ／Ｌ，且均有程度不同的症状及体征。为保护工人健康，应加强劳动保护措施与科学管理，降低药尘浓度，适当延长生产人员每年脱离接触１８甲粉尘作业的间歇时间（如３个月），并严格避免非生产性１８甲粉尘的污染与接触。
In order to explore the health effects of norethindrone (18 A) dust on the production workers, the average total concentration of dust in the air of two raw material medicine factories producing 18 A in our country was investigated and measured. The average concentration of total dust in the air was 6.35 mg / m3.31 Personnel (female 22, male 9) mainly in drowsiness, nausea and women’s menstrual disorders, bleeding during interphase and abnormal liver function, blood glucose and other clinical changes significantly different from the control group. Nearly half of the patients returned to normal levels and most of the symptoms disappeared two months after they were out of contact with 18 A. However, more than half of the patients still had an average blood level of 538 pmol / L with some symptoms. When the re-induction of 18 A 3 months after birth, the mean plasma level of 2584pmol / L, and have varying degrees of symptoms and signs. In order to protect the health of workers, labor protection measures and scientific management should be stepped up to reduce the concentration of dusts. The intermittent time (for example, 3 months) for the production workers to get out of contact with 18 dusts per year should be appropriately prolonged and the non-productive 18-dust Pollution and exposure.