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HBsAg是乙型肝炎病毒(HBV)的外壳.它是一个十分复杂的巨型蛋白分子.1972年Matanhashi等发现,HBsAg阳性血清能凝集用聚合人血清白蛋白(PHSA)包被的红细胞,实验证实该现象是由于HBsAg具有聚合人白蛋白受体(PHSAr)而引起的。肝脏是处理蛋白质的重要场所,在正常情况下,老化的人血清白蛋白形成PHSA经肝脏处理后清除,因此PHSA存在极少,并可被PHSA抗体(AAA)所清除,然而HBV感染并导致肝功能减弱后,体内出现大量PHSA,它既能诱发AAA的大量产生,又可能与HBsAg—PHSAr
HBsAg is the outer shell of Hepatitis B virus (HBV), and it is a very complex giant protein molecule. In 1972, Matanhashi et al. Found that HBsAg positive serum can agglutinate erythrocytes coated with polymerized human serum albumin (PHSA) The phenomenon is due to the HBsAg having a polymerized human albumin receptor (PHSAr). The liver is an important site for protein handling. Under normal conditions, aged human serum albumin is cleared from the liver by the formation of PHSA. As a result, PHSA is rare and cleared by PHSA antibodies (AAA), whereas HBV infects and causes the liver After weakened function, a large number of PHSA in vivo, it can induce a large number of AAA production, but also with HBsAg-PHSAr