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本文结合药物透皮吸收的有关因素,探讨了表面活性剂对药物透皮吸收的影响.作者认为这种影响表现于:表面活性剂能改变药物的分配系数或直接作用于皮肤从而促进药物的透皮吸收;而在很多场合下这两种作用同时发生.例如水扬酸,pH较低时呈分子型,药物容易进入表面活性剂的胶团内部,使游离药物减少,透皮吸收量降低;反之,pH较高时,游离药物增加,透皮吸收量提高.直接作用于皮肤的有如下几种情况:阳离子型表面活性剂可能作用于角质层中的角蛋白纤维,
In this paper, we discuss the influence of surfactant on the transdermal absorption of drugs in combination with the related factors of transdermal drug absorption.The authors think this effect is manifested in that the surfactant can change the distribution coefficient of the drug or directly act on the skin to promote the penetration of the drug For example, salicylic acid, when pH is low, is of molecular type, the drug easily enters into the inside of the micelles of the surfactant, reducing the free drug and decreasing the transdermal absorption amount; on the other hand, Conversely, higher pH results in an increase of free drug and an increase of transdermal absorption There are several cases of direct action on the skin: cationic surfactants may act on keratin fibers in the stratum corneum,