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骨质疏松是一种严重的老年性疾病。全球骨质疏松的患者约2亿人。在中国,骨质疏松的患者超过9 000万,约占总人口的7.1%。骨质疏松症及其引起的骨折位居常见疾病的第7位,严重威胁着中、老年人的健康,成为全球公共卫生问题之一。骨质疏松与成骨细胞/破骨细胞功能障碍有关。影响成骨细胞/破骨细胞增殖、分化及功能的各种因素是骨质疏松发病的重要原因。在上皮组织中高度表达的钙离子通道TRPV5/TRPV6,对全身钙离子代谢有着非常重要的作用。认识骨组织代谢调控因子TRPV5/TRPV6在骨质疏松发病机制中的作用,
Osteoporosis is a serious senile disease. About 200 million people worldwide have osteoporosis. In China, there are more than 90 million osteoporosis patients, accounting for about 7.1% of the total population. Osteoporosis and the fractures caused by it are the 7th among common diseases, posing a serious threat to the health of middle and elderly people and becoming one of the global public health problems. Osteoporosis is associated with osteoblast / osteoclast dysfunction. Various factors that influence the proliferation, differentiation and function of osteoblasts / osteoclasts are the important causes of osteoporosis. The highly expressed calcium channel TRPV5 / TRPV6 in epithelial tissues plays a very important role in systemic calcium metabolism. To understand the role of bone metabolism regulator TRPV5 / TRPV6 in the pathogenesis of osteoporosis,