目的　提高临床对引起慢性肝病药物的认识。方法　回顾性分析确诊的 4 0例慢性药物性肝病的临床资料。结果　药物诱发慢性肝炎 18例 ,慢性肝内胆汁淤积 7例 ,肝硬化 3例 ,脂肪肝 6例 ,肝脏腺瘤 3例 ,肝静脉血栓形成 2例 ,肝肉芽肿 1例 ;4 0例中治愈 35例 ( 87 5 % ) ,好转 4例 ( 10 0 % ) ,死亡 1例 ( 2 5 % )。常见诱导慢性肝病的药物有抗结核药、化疗药、镇静安眠抗惊厥药、非甾体类抗炎药、抗雌激素、降脂药等。结论　诱导慢性肝病的药物应引起临床上的重视 Objective To improve the clinical knowledge of drugs that cause chronic liver disease. Methods Retrospective analysis of 40 cases of chronic drug-induced liver disease clinical data. Results Drug induced chronic hepatitis in 18 cases, chronic intrahepatic cholestasis in 7 cases, cirrhosis in 3 cases, fatty liver in 6 cases, liver adenoma in 3 cases, hepatic vein thrombosis in 2 cases, liver granuloma in 1 case; 40 cases were cured 35 cases (87.5%), 4 cases improved (100%) and 1 died (25%). Common drugs for inducing chronic liver disease are anti-TB drugs, chemotherapy drugs, sedation and anticonvulsant drugs, non-steroidal anti-inflammatory drugs, anti-estrogen, lipid-lowering drugs. Conclusion Induction of chronic liver disease drugs should cause clinical attention