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目的评价双水平正压(BiPAP)通气联合可拉明治疗慢性阻塞性肺疾病(COPD)肺性脑病的临床疗效。方法86例COPDII型呼吸衰竭患者根据意识障碍的严重程度分为A、B组(A组:合并轻型肺性脑病;B组:合并中型肺性脑病)。各组再随机分为对照组及治疗组,在综合治疗基础上分别给予BiPAP通气及BiPAP通气联合可拉明治疗。观察各组治疗无效率。结果A组中治疗组及对照组治疗无效率分别为16.7%(5/30)、40.0%(12/30),差异有显著性(P<0.05);B组中治疗组及对照组治疗无效率分别为69.2%(9/13),76.9%(10/13),差异无显著性(P>0.05)。结论BiPAP通气联合可拉明治疗COPD合并轻型肺性脑病有较显著疗效,但对COPD合并中、重型肺性脑病,BiPAP通气联合可拉明治疗无显著疗效。
Objective To evaluate the clinical efficacy of bi-level positive pressure (BiPAP) ventilation combined with cilamine in the treatment of chronic obstructive pulmonary disease (COPD) pulmonary encephalopathy. Methods Eighty - six patients with COPD type II respiratory failure were divided into groups A and B according to the severity of disturbance of consciousness (group A: with mild pulmonary encephalopathy; group B: with middle pulmonary encephalopathy). Each group was randomly divided into control group and treatment group, on the basis of comprehensive treatment were given BiPAP ventilation and BiPAP ventilation combined with cocaine treatment. Observe the ineffectiveness of each treatment group. Results The ineffective rates of treatment in group A and control group were 16.7% (5/30) and 40.0% (12/30) respectively, with significant difference (P <0.05). The treatment group and control group in group B had no effect The efficacies were 69.2% (9/13) and 76.9% (10/13) respectively, with no significant difference (P> 0.05). Conclusion BiPAP ventilation combined with calamine in COPD with mild pulmonary encephalopathy has a significant effect, but no significant effect on COPD with moderate and severe pulmonary encephalopathy, BiPAP ventilation combined with cocaine.