应用 Ｐ Ｃ Ｒ 技术对１００ 例 Ｎ Ｉ Ｄ Ｄ Ｍ 患者和８６ 例正常人进行 Ｇ Ｃ Ｋ， Ｈ Ｋ２ 基因微卫星多态标志与 Ｎ Ｉ Ｄ Ｄ Ｍ关系的研究． 结果： Ｎ Ｉ Ｄ Ｄ Ｍ 患者 Ｇ Ｃ Ｋ 基因中的１ ， １ 及２ ， ２ 型频率均明显高于正常对照组（ χ２ 分别为４７８及７０１ ， Ｐ＜ ００５） ， ２ ， １ 型明显低于正常对照组 （ χ２ ＝ １３１３ ， Ｐ＜ ００５） ； Ｈ Ｋ２ ３ 种基因型频率在两组均无差异（ χ２ ＝ ２６２ ， Ｐ＞ ００５） ． 结果表明： Ｇ Ｃ Ｋ 基因与 Ｎ Ｉ Ｄ Ｄ Ｍ 有关而 Ｈ Ｋ２ 基因与 Ｎ Ｉ Ｄ Ｄ Ｍ 无关联． The relationship between G C K, H K2 gene microsatellite polymorphism markers and N IDDM was studied in 100 patients with NIDDM and 86 healthy controls using PCR technique. Results: The frequencies of type 1, 1 and 2, 2 of G C K gene in patients with NIDDM were significantly higher than those in controls (χ2 = 478 and 701, P <005), 2 (Χ2 = 1313, P <005). There was no significant difference in the frequency of genotypes of H 2 between the two groups (χ2 = 262, P> 005). The results showed that the G C K gene was associated with N I D D M and the H K 2 gene was not associated with N I D D M.