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目的了解国内主要地区临床分离变形杆菌属、沙雷菌属、枸橼酸杆菌属、摩根菌属及普罗威登菌属细菌对常用抗菌药物的敏感性和耐药性。方法对CHINET细菌耐药性监测网临床分离菌,采用纸片扩散法或自动化仪器法按统一方案进行药物敏感性试验。结果 2005—2014年分离出变形杆菌属、沙雷菌属、枸橼酸杆菌属、摩根菌属、普罗威登菌属共计21 663株。10年间,变形杆菌属细菌的检出率呈上升趋势:2005年为1.41%,2014年为2.09%;沙雷菌属细菌的检出率呈上升趋势:2005年为0.99%,2014年为1.28%;枸橼酸杆菌属、摩根菌属和普罗威登菌属细菌的检出率基本无变化。变形杆菌属对头孢哌酮-舒巴坦、哌拉西林-他唑巴坦、头孢他啶、头孢西丁、阿米卡星、替加环素耐药率低于10%。沙雷菌属对头孢哌酮-舒巴坦、哌拉西林-他唑巴坦、阿米卡星、替加环素耐药率低于10%。枸橼酸杆菌属对头孢哌酮-舒巴坦、哌拉西林-他唑巴坦、头孢吡肟、阿米卡星、替加环素耐药率低于20%。摩根菌属对头孢哌酮-舒巴坦、哌拉西林-他唑巴坦、头孢吡肟、阿米卡星、替加环素耐药率低于10%。普罗威登菌属对头孢哌酮-舒巴坦、哌拉西林-他唑巴坦、头孢吡肟、头孢西丁、替加环素耐药率低于20%。结论 10年中细菌耐药性仍呈增长趋势,严格采取有效的感控措施及合理用药是减缓耐药性增长的有效方法。
Objective To understand the sensitivity and resistance of commonly used antibacterials to Proteus, Serratia, Citrobacter, Morganella and Providencia bacteria isolated from clinics in major areas of China. Methods The clinical isolates from CHINET bacterial drug resistance monitoring network were tested for drug susceptibility according to a unified protocol using disk diffusion method or automated instrumentation. Results A total of 21 663 strains of Proteus, Serratia, Citrobacter, Morganella and Providencia were isolated from 2005 to 2014. In 10 years, the detection rate of Proteus bacteria is on the rise: 1.41% in 2005 and 2.09% in 2014; the detection rate of bacteria in Serratia bacteria is on the rise: from 0.99% in 2005 to 1.28% in 2014 %; Citrobacter genus, genusMotorrhoeaAnd Providencia bacteria no significant change in the detection rate. Proteus resistance to cefoperazone-sulbactam, piperacillin-tazobactam, ceftazidime, cefoxitin, amikacin, tigecycline resistance rate of less than 10%. Serratia to cefoperazone - sulbactam, piperacillin - tazobactam, amikacin, tigecycline resistance rate of less than 10%. Citrobacter cefoperazone - sulbactam, piperacillin - tazobactam, cefepime, amikacin, tigecycline resistance rate of less than 20%. The resistance rate of Morgan genus to cefoperazone-sulbactam, piperacillin-tazobactam, cefepime, amikacin and tigecycline was less than 10%. Providencia was less than 20% resistant to cefoperazone-sulbactam, piperacillin-tazobactam, cefepime, cefoxitin and tigecycline. Conclusions Bacterial drug resistance still shows an increasing trend in 10 years. Strictly adopting effective control measures and rational drug use is an effective method to slow down the growth of drug resistance.