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目的:观察高渗盐水联合沙丁胺醇雾化吸入治疗小儿毛细支气管炎疗效。方法:选取2012年1月~2013年2月在我院接受治疗的毛细支气管炎患儿78例,随机分为治疗组和对照组,每组各39例。两组均采用综合性治疗及对症处理,在此基础上,对照组给予生理盐水联合沙丁胺醇雾化吸入,治疗组给予3.6%高渗盐水联合沙丁胺醇雾化吸入。观察两组痰液炎性细胞计数差值及临床疗效。结果:治疗组总有效率94.87%(37/39),对照组总有效率82.05%(32/39),显著差异有统计意义(P<0.05)。治疗组患儿雾化吸入前和治疗5 d后痰液细胞总数、淋巴细胞数和中性淋巴细胞数均低于对照组(P<0.01)。结论:联合使用3.6%的高渗盐水和雾化吸入沙丁胺醇,可有效减少炎症细胞数量,缓解气道水肿与阻塞,缓解临床症状,缩短病程,值得推广。
Objective: To observe the therapeutic effect of hypertonic saline and salbutamol inhalation on children bronchiolitis. Methods: 78 children with bronchiolitis treated in our hospital from January 2012 to February 2013 were randomly divided into treatment group and control group, with 39 cases in each group. Both groups were treated with comprehensive treatment and symptomatic treatment. On the basis of this, the control group was treated with inhalation of saline combined with salbutamol inhalation. The treatment group was given inhalation of 3.6% hypertonic saline combined with salbutamol. Differences in sputum inflammatory cell count and clinical efficacy between the two groups were observed. Results: The total effective rate was 94.87% (37/39) in the treatment group and 82.05% (32/39) in the control group, with significant difference (P <0.05). The total number of sputum cells, the number of lymphocytes and the number of neutrophils in the treatment group before and after 5 days of inhalation were all lower than those in the control group (P <0.01). Conclusion: Combined use of 3.6% hypertonic saline and nebulized albuterol can effectively reduce the number of inflammatory cells, relieve airway edema and obstruction, relieve clinical symptoms and shorten the course of disease, which is worth promoting.