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目的探讨血清胸苷激酶1(thymidinekinase-1,TK1)检测在非小细胞肺癌患者根治手术中的意义。方法对44例非小细胞肺癌患者行根治手术，术前检测血清TK1，术后随访6~18个月，其中20例患者在术后随访时检测血清TK1，分析各临床病理因素及血清TK1水平与术后转移复发的关系。结果术前血清TK1高水平(>0.94pM)患者术后无复发生存率明显低于术前血清TK1低水平(≤0.94pM)患者(<0.05)。联合术前TNM分期、肿瘤分化程度及TK1水平，可明显提高预测术后转移复发的敏感性(95%)。肺癌患者术后1个月血清TK1浓度较术前显著下降(<0.05)，术后随访中转移复发时血清TK1水平明显高于未转移复发的患者(0.94pM)was significantly lower than the patients with preoperative low serum TK1 level (≤0.94pM)( <0.05).Combined with preoperative TNM staging,tumor dif erentiation degree and the level of TK1,the sensitivity of prediction of recur ence and metastasis after operation can be significantly improved (95%).The serum TK1 levels decreased one month after operation ( <0.05).After operation,the levels of serum TK1 in patients with recurrence and metastasis were higher than the others ( <0.05).Conclusion The serum thymidine kinase 1 detection has a certain value in prediction and diagnosis of recur ence and metastasis.