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目的探讨缺血性脑卒中与血浆纤维蛋白原之间关系。方法检测128例缺血性脑卒中患者(急性期和恢复期)及30名正常对照者血浆中纤维蛋白原浓度,并与神经功能缺损程度进行相关分析。结果①缺血性脑卒中患者急性期与恢复期纤维蛋白原浓度显著高于对照组;②纤维蛋白原浓度与神经功能缺损程度评分显著正相关(P<0.01)。结论缺血性脑卒中患者急性期纤维蛋白原浓度显著升高,纤维蛋白原可能参与了缺血性脑损伤的病理过程,并间接反映病情程度;恢复期纤维蛋白浓原度仍高于对照组,提示恢复期患者仍需积极治疗。
Objective To investigate the relationship between ischemic stroke and plasma fibrinogen. Methods Plasma concentrations of fibrinogen were measured in 128 patients with ischemic stroke (acute phase and convalescent phase) and 30 normal controls, and their correlations were analyzed with the degree of neurological deficits. Results ① The concentration of fibrinogen in acute and convalescent phase of ischemic stroke patients was significantly higher than that of control group. (2) The concentration of fibrinogen was positively correlated with the degree of neurological deficit (P <0.01). Conclusion The concentration of fibrinogen in acute phase of ischemic stroke patients is significantly increased. Fibrinogen may be involved in the pathological process of ischemic brain injury and indirectly reflect the severity of illness. The concentration of fibrin in convalescent stage is still higher than that in control group , Suggesting that patients still need active treatment during convalescence.