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1957年中国科学院药物研究所在硫醇锑化会物研究中找出二巯基丁二酸锑钠(简称巯锑钠或Sb-58)。小白鼠毒性试验结果,其毒性仅力吐酒石的1/50左右,对实验性血吸虫病有显著的疗效,且可以肌肉注射,遂推荐于临床试用。1958年开始,中国医学科学院寄生虫病研究所等单位以Sb-58三天与十二天等疗法,对一千余例不同类型血吸虫病患者治疗的观察结果表明,Sb-58的稳定度尚可改进,其疗效不亚于吐酒石,且可以肌肉注射。1959年浙江农业科学
In 1957, Institute of Materia Medica, Chinese Academy of Sciences found antimony dimercaptosuccinate (referred to as antimony sulfite or Sb-58) in the research of thiols antimony compounds. Toxicity test results in mice, the toxicity of only spit tofu spit about 1/50 of experimental schistosomiasis has a significant effect, and can be intramuscularly injected, then recommended for clinical trials. From 1958 onwards, the Institute of Parasitic Diseases, Chinese Academy of Medical Sciences and other units to Sb-58 three days and twelve days of treatment, the treatment of more than a thousand different types of schistosomiasis patients showed that the stability of Sb-58 Can be improved, its efficacy no less than spit tartar, and intramuscular injection. 1959 Zhejiang Agricultural Sciences