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目的:本研究考察了Gemini作为生物粘附材料,评价其在大鼠体胃肠道的不同粘附程度。方法:采用大鼠离体肠及在体实验法,通过测定辅酶Q_(10)在不同胃肠道区域含量,来评价Gemini的粘附性。结果:大鼠离体肠实验实验结果表明,随着Gemini含量增加,药物浓度最多可达15μg·m L~(-1)。大鼠在体实验结果表明,含有Gemini的制剂粘附在胃壁上可达5h以上,而后向回肠转移。结论:Gemini能够起到生物粘附的作用,且该作用随着Gemini含量增加而增加;Gemini做为胃粘附或回肠粘附材料效果更佳。
OBJECTIVE: In this study, Gemini was used as a bioadhesive material to evaluate its different adhesion in rat gastrointestinal tract. Methods: The adhesion of Gemini was evaluated by measuring the content of coenzyme Q_ (10) in different gastrointestinal tract regions in vitro and in vivo. Results: The experimental results of rat intestinal in vitro showed that with the increase of Gemini content, the drug concentration could reach up to 15μg · m L -1. In vivo experiments in rats showed that preparations containing Gemini adhered to the stomach wall up to 5h, and then transferred to the ileum. CONCLUSION: Gemini can act as a bioadhesive, and this effect increases with increasing Gemini content. Gemini is more effective as a gastric adhesion or ileal adherence material.