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目的:观察益气逐瘀药粉抗肿瘤的作用。方法:将小鼠随机分为5组.4组移植 H_(22)腹水型肝癌细胞,并予各组相应的治疗,2周后观察抑瘤率、存活率、小鼠脾脏组织淋巴细胞激活的杀伤(LAK)细胞和自然杀伤(NK)细胞的活性,正常小鼠肝组织、荷瘤小鼠肝癌组织中的过氧化物歧化酶(SOD)和过氧化氢酶(CAT)的活性、过氧化脂质(LPO)含量。结果:化疗组抑瘤率为80.51%,存活率为31.25%;中药组抑瘤率为60.16%,存活率为93.75%;中药加化疗组抑瘤率为80.93%,存活率为56.25%;与对照组比较,差异均有显著性(P<0.05或 P<0.01)。该中药粉能提高荷瘤鼠 LAK 细胞和 NK 细胞活性;降低肝癌组织中 SOD 和CAT 的酶活性;与对照组比较,差异均有显著性(P<0.01)。结论:益气逐瘀药粉有一定直接杀伤肿瘤细胞的作用,对化疗有增效减毒作用,能调节免疫功能,影响癌组织自由基代谢,可应用于消化道肿瘤的辅助治疗。
Objective: To observe the anti-tumor effect of Yiqi Zhuyu Powder. METHODS: Mice were randomly divided into 5 groups. The 4 groups were transplanted H_(22) ascitic hepatoma cells and treated with each group. After 2 weeks, the tumor inhibition rate, survival rate, and lymphocyte activation of mouse spleen tissue were observed. Activity of killer (LAK) cells and natural killer (NK) cells, activity of superoxide dismutase (SOD) and catalase (CAT) in liver tissue of normal mice, tumor-bearing mouse liver cancer, and peroxidation Lipid (LPO) content. Results: In the chemotherapy group, the tumor inhibition rate was 80.51% and the survival rate was 31.25%. The inhibition rate of the Chinese medicine group was 60.16% and the survival rate was 93.75%. The tumor inhibition rate of the traditional Chinese medicine plus chemotherapy group was 80.93%, and the survival rate was 56.25%; Compared with the control group, the differences were significant (P<0.05 or P<0.01). The traditional Chinese medicine powder can increase the activity of LAK cells and NK cells in tumor-bearing mice and reduce the enzyme activities of SOD and CAT in liver cancer tissues. Compared with the control group, the differences are significant (P<0.01). Conclusion: Yiqi Zhuyu Powder has a direct effect on killing tumor cells, has synergistic and attenuating effects on chemotherapy, can regulate immune function, and affects free radical metabolism of cancer tissues. It can be used for the adjuvant treatment of digestive tract tumors.