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自身免疫性肝炎(Autoimmune hepatitis,AIH)是一种病因和发病机制未明、异常自身免疫反应介导的慢性进行性肝脏炎症性疾病,女性易患。其临床特点为不同程度的血清转氨酶升高、高丙种球蛋白血症、血清中出现自身抗体,常伴发其他肝外自身免疫性疾病。目前临床面临最大的挑战是如何在肝硬化之前做到早期诊断,在治疗疾病的同时避免免疫抑制剂的副作用。本文以药物研究为核心,概述近几年AIH治疗的研究进展。
Autoimmune hepatitis (AIH) is a chronic and progressive liver inflammatory disease mediated by abnormal autoimmune reaction in unknown etiology and pathogenesis. The clinical features of varying degrees of elevated serum transaminases, hypergammaglobulinemia, serum autoantibodies, often accompanied by other extrahepatic autoimmune diseases. Currently the biggest clinical challenge is how to make early diagnosis before cirrhosis, the treatment of diseases while avoiding the side effects of immunosuppressive agents. In this paper, drug research as the core, overview of AIH treatment in recent years, research progress.