Sharpe氏首先提出应用消炎痛抑制前列腺素合成的药理作用来关闭动脉导管。有两篇文章报告用消炎痛治疗伴有呼吸窘迫综合征的早产儿动脉导管未闭,50例中49例获得成功。本组应用消炎痛治疗11例动脉导管未闭伴有严重呼吸窘迫综合征的早产儿中仅2例的导管得以永久性关闭;另2例导管用药24后小时内暂时性关闭,在48～72小时后,左向右的分流又复发了;其余7例患儿的杂音持续存在,4例曾进 Sharpe first proposed the use of indomethacin inhibition of prostaglandin synthesis pharmacological effects to close the ductus arteriosus. Two articles report the use of indomethacin in the treatment of patent ductus arteriosus in preterm infants with respiratory distress syndrome. Forty-nine of 50 patients were successful. Indomethacin in this group of 11 cases of patent ductus arteriosus with severe respiratory distress syndrome in only 2 cases of premature infants were permanently closed catheterization; the other 2 catheterization medication within 24 hours of temporary closure in 48 to 72 Hours later, left to right shunt recurrence; the remaining seven cases of children with persistent murmur, 4 cases have been